Begin by preheating your oven to 350°F (175°C). While it heats, grease a 9x5 inch loaf pan with cooking spray or butter to ensure your Sausage and Cheese Bread comes out easily.

In a skillet over medium heat, crumble and cook the pork sausage with the chopped onion until both are golden brown and the sausage is fully cooked, about 8-10 minutes. Stir occasionally to break up the sausage. Once done, drain any excess fat and set the mixture aside to cool while you gather the other ingredients.

In a large mixing bowl, crack one egg and add the grated cheddar cheese, Parmesan cheese, Texas Pete hot sauce, salt, and red pepper flakes. Mix the ingredients well with a whisk or fork until they are fully combined and creamy.

Gently stir in the Bisquick baking mix, milk, and mayonnaise to the wet mixture. Combine until just incorporated—avoid overmixing to keep the bread light and fluffy. Fold in the cooled sausage and onion mixture.

Pour the batter into the prepared loaf pan, smoothing the top with a spatula for an even surface. Place the pan in the preheated oven and bake for 45-50 minutes.

Once baked, remove the bread from the oven and allow it to cool in the pan for 10 minutes. After cooling, carefully turn the loaf out onto a plate. Slice your Sausage and Cheese Bread and serve warm.